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Cyclosporine A rescues the influenza virus fusion with IFITM3-expressing cells by relocating the restriction factor to intraluminal vesicles of multivesicular bodies

ABSTRACT Interferon-induced transmembrane protein 3 (IFITM3) blocks fusion of many enveloped viruses with endosomes, likely by rigidifying the cell membrane. We and others have previously reported that cyclosporine A (CsA) treatment rescues the ability of the influenza A virus (IAV) to fuse with and...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sergey A. Buth, Mariana Marin, You Zhang, Ori Avinoam, Gregory B. Melikyan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2026-04-01
Schriftenreihe:Journal of Virology
Schlagworte:
influenza virus
viral fusion
hemifusion
multivesicular bodies
intraluminal vesicles
IFITM3
Online-Zugang:https://journals.asm.org/doi/10.1128/jvi.02045-25
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