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Type 2 diabetes impacts DNA methylation in human sperm

Abstract Aims/hypothesis Disorders of the reproductive system, including hypogonadism and reduced fertility, are an under-recognized complication of diabetes. Based on experimental data in mice, hyperglycemia and obesity may modify epigenetic marks in sperm and impact health and development of offsp...

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Principais autores: Lei Su, Jonathan M. Dreyfuss, Rafael Ferraz Bannitz, Danielle Wolfs, Georgia Hansbury, Lauren Richardson, Charnice Charmant, Jay Patel, Elizabeth S. Ginsburg, Catherine Racowsky, Ruby Fore, Vissarion Efthymiou, Jessica Desmond, Allison Goldfine, Anne Ferguson-Smith, Hui Pan, Marie-France Hivert, Elvira Isganaitis, Mary Elizabeth Patti
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2025-03-01
Series:Clinical Epigenetics
Assuntos:
DNA methylation
Spermatozoa
Epigenetics
Type 2 diabetes
Semen quality
Acceso en liña:https://doi.org/10.1186/s13148-025-01853-9
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