Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics

Mesothelin is a glypiated, cell-surface glycoprotein expressed at low levels on normal mesothelium but overexpressed by many cancers. Implicated in cell adhesion and multiple signaling pathways, mesothelin’s precise biological function and overall structure remain undefined. Antibodies targeting mes...

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Autors principals:	Ida Lin, Peter B. Rupert, Kristina Pilat, Raymond O. Ruff, Della J. Friend, Man Kid Chan, Midori Clarke, Benjamin G. Hoffstrom, Jane Carter, Soheil Meshinchi, Ashok D. Bandaranayake, Christopher Mehlin, James M. Olson, Roland K. Strong, Colin E. Correnti
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-08-01
Col·lecció:	Frontiers in Drug Discovery
Matèries:	mesothelin antibody CD3 bispecific T cell cancer
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fddsv.2023.1216516/full
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