Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels

Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. Given the critical role of liver in iron storage and metabolism, ferroptosis, characterized by iron-dependent lipid peroxidation and oxidative damage, has become a potential therapy for HCC. Recent research i...

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Egile Nagusiak:	Jieyou Li, Guibing Wu, Hairou Su, Manfeng Liang, Shengpei Cen, Yandan Liao, Xiangjun Zhou, Guantai Xie, Zihao Deng, Wenchong Tan, Yan Li, Wang Xiao, Lixia Liu, Jinxin Zhang, Zhenming Zheng, Yaotang Deng, Yaling Huang, Xiongjie Shi, Yilin Liu, Guowei Zhang, Xuemei Chen
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2025-09-01
Saila:	Redox Biology
Gaiak:	Ferroptosis Hsp90α C-terminal domain VDAC1 Carbonylation HMOX1 GPX4
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2213231725001855
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