Blockade of Sialylation with Decrease in Polysialic Acid Levels Counteracts Transforming Growth Factor β1-Induced Skin Fibroblast-to-Myofibroblast Transition

Aberrant sialylation with overexpression of the homopolymeric glycan polysialic acid (polySia) was recently reported in fibroblasts from fibrotic skin lesions. Yet, whether such a rise in polySia levels or sialylation in general may be functionally implicated in profibrotic activation of fibroblasts...

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Autori principali:	Bianca Saveria Fioretto, Irene Rosa, Alessia Tani, Elena Andreucci, Eloisa Romano, Eleonora Sgambati, Mirko Manetti
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2024-06-01
Serie:	Cells
Soggetti:	skin fibroblasts myofibroblasts skin fibrosis fibroblast-to-myofibroblast transition TGFβ1 sialylation
Accesso online:	https://www.mdpi.com/2073-4409/13/12/1067
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