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Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery

The functions of RNA-dependent RNA polymerases (RdRps) in RNA viruses are demonstrably modulated by native substrates of dynamic and interconvertible conformational ensembles. Many of these are populated by essential flexible or intrinsically disordered regions (IDRs) that lack a stable three-dimens...

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Principais autores: Rachid Tahzima, Justine Charon, Adrian Diaz, Kris De Jonghe, Sebastien Massart, Thierry Michon, Wim Vranken
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-08-01
Serier:Frontiers in Virology
Fag:
RNA-dependent RNA polymerase
RNA virus discovery
conformational ensembles
intrinsic disorder (IDP/IDR)
structural biology
AlphaFold2 (AF2)
Online adgang:https://www.frontiersin.org/articles/10.3389/fviro.2025.1501616/full
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