Chiral metal nanozyme-enabled SOD2 activation and siRNA delivery cooperatively mitigating chronic heart failure

Doxorubicin (DOX) treatment can lead to intracellular iron overload in cardiomyocytes, triggering excessive generation of reactive oxygen species (ROS) and resulting in cardiotoxicity. Superoxide dismutase (SOD) effectively scavenges ROS, and its catalytic activity depends on the binding of metal io...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Zekun Wang, Ruofei Zhang, Yanyu Hu, Qile Song, Xiaoyan Fu, Yifan Wang, Mei Chen, Kelong Fan, Cundong Fan, Dongdong Sun
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	KeAi Communications Co., Ltd. 2026-04-01
Schriftenreihe:	Bioactive Materials
Schlagworte:	Doxorubicin Chronic heart failure Ferroptosis Bionic chiral MnO2 nanozymes SOD2 activation
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2452199X25005791
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!