Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review

Abstract In the human heart, the rapid delayed rectifier K+ current (IKr) contributes significantly to ventricular action potential (AP) repolarization and to set the duration of the QT interval of the surface electrocardiogram (ECG). The pore‐forming (α) subunit of the IKr channel is encoded by KCN...

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Detalhes bibliográficos

Principais autores:	Aziza El Harchi, Oriane Brincourt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2022-08-01
coleção:	Journal of Arrhythmia
Assuntos:	Long QT syndrome hERG K+ channel pharmacology mutation arrhythmia hERG agonists
Acesso em linha:	https://doi.org/10.1002/joa3.12741
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