Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

<p>Abstract</p> <p>Mammalian target of rapamycin (mTOR) can be found in two multi-protein complexes, i.e. mTORC1 (containing Raptor) and mTORC2 (containing Rictor). Here, we investigated the mechanisms by which mTORC1 and mTORC2 are activated and their downstream targets in response to platelet-deri...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Razmara Masoud, Heldin Carl-Henrik, Lennartsson Johan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2013-01-01
Serie:	Cell Communication and Signaling
Soggetti:	PDGF PI3K mTOR Rictor Raptor Akt PLC PKC PLD S6
Accesso online:	http://www.biosignaling.com/content/11/1/3
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!