Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism.

Dis3L2 is a highly conserved 3'-5' exoribonuclease which is mutated in the human overgrowth disorders Perlman syndrome and Wilms' tumour of the kidney. Using Drosophila melanogaster as a model system, we have generated a new dis3L2 null mutant together with wild-type and nuclease-dead genetic lines...

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Principais autores:	Benjamin P Towler, Amy L Pashler, Hope J Haime, Katarzyna M Przybyl, Sandra C Viegas, Rute G Matos, Simon J Morley, Cecilia M Arraiano, Sarah F Newbury
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2020-12-01
coleção:	PLoS Genetics
Acesso em linha:	https://doi.org/10.1371/journal.pgen.1009297
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