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Skewness and Kurtosis of mRNA Distributions in Stochastic Gene Transcription with Promoter Switching

Gene transcription is inherently stochastic, and promoter-switching-induced transcriptional bursting generates substantial cell-to-cell variability in mRNA abundance. Such variability is commonly characterized by the mean and variance; however, these low-order statistics fail to capture the geometri...

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Principais autores: Shumin Tan, Wangyang Wu, Qiwen Sun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-03-01
Serier:Mathematics
Fag:
stochastic gene expression
promoter switching
transcriptional bursting
skewness and kurtosis
higher-order moments
Online adgang:https://www.mdpi.com/2227-7390/14/6/1074
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