The kpc-1 3'UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship.

A recently reported Schizophrenia-associated genetic variant in the 3'UTR of the human furin gene, a homolog of C. elegans kpc-1, highlights an important role of the furin 3'UTR in neuronal development. We isolate three kpc-1 mutants that display abnormal dendrite arborization in PVD neurons and def...

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Autores principales:	Mushaine Shih, Yan Zou, Tarsis Ferreira, Nobuko Suzuki, Eunseo Kim, Chiou-Fen Chuang, Chieh Chang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2024-08-01
Colección:	PLoS Genetics
Acceso en línea:	https://doi.org/10.1371/journal.pgen.1011362
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