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Integrated multi-omics reveal lactate metabolism-related gene signatures and PYGL in predicting HNSCC prognosis and immunotherapy efficacy

Abstract Background Head and neck squamous cell carcinoma (HNSCC) treatment faces significant clinical challenges. Lactate metabolism plays a crucial role in the initiation of many cancers and the tumor microenvironment (TME). However, the prognostic significance of lactate metabolism-related genes...

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Principais autores: Xiaochuan Chen, Zhangying Jiang, Junping Pan, Wenqian Xu, Ying Li, Xin Chen, Yuhui Pan, Youliang Weng, Dan Hu, Sufang Qiu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-04-01
coleção:BMC Cancer
Assuntos:
Head and neck squamous cell carcinoma
Lactate metabolism
Tumor microenvironment
Prognostic model
PYGL
Acesso em linha:https://doi.org/10.1186/s12885-025-13982-8
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