Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness

BackgroundExcessive daytime sleepiness (EDS) is a common non-motor symptom in Parkinson’s disease (PD) that negatively impacts quality of life. Although biomarkers of brain structure, function, and neurodegeneration have been studied, their interactions in EDS remain unclear. This study explores the...

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Główni autorzy:	Jieyu Chen, Guoliang Jiang, Yongyun Zhu, Chunyu Liang, Chenxi Liu, Jianzhun Chen, Baiyuan Yang, Xinglong Yang
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2025-08-01
Seria:	Frontiers in Aging Neuroscience
Hasła przedmiotowe:	cortical thickness mediation analysis Parkinson’s disease neurofilament light chain excessive daytime sleepiness functional connectivity
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1645290/full
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