A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia

Abstract Microglia engulf dying neurons through efferocytosis, a critical function in both development and disease. How microglia process the engulfed neuronal material—especially lipids—remains poorly understood, despite its central role in neurodegeneration. Thus, we developed HuZIBRA, a scalable...

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Autors principals:	Ambra Villani, Jana Wittmann, Tamara Wyss, Izaskun Mallona, Irene Santisteban Ortiz, Nathalie Tichy, Corinna Maria Biermeier, Monique Pena, Ayush Aditya Pal, Darren Gilmour, Simon T. Schafer, Francesca Peri
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-04-01
Col·lecció:	Communications Biology
Accés en línia:	https://doi.org/10.1038/s42003-026-09948-6
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