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The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis

Abstract Background Gremlin-1 (GREM1) and Gremlin-2 (GREM2) are bone morphogenetic protein antagonists that play important roles in organogenesis, tissue differentiation, and tissue homeostasis. Although GREM1 has been reported to be involved in promoting various cancers, little has been reported ab...

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Main Authors: Jiwoo Jung, Na Hui Kim, Minji Kwon, Jayeon Park, Dayeon Lim, Youjin Kim, World Gil, Ye Hwang Cheong, Sin-Aye Park
Format: Artigo
Language:Inglês
Published: BMC 2023-10-01
Series:Breast Cancer Research
Subjects:
Gremlin-2
3T3-L1 cells
Adipocytes
IL-6
Breast cancer cells
Cancer progression
Online Access:https://doi.org/10.1186/s13058-023-01732-2
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