LRRK2 Structure-Based Activation Mechanism and Pathogenesis
Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been identified as a genetic risk factor for both sporadic and familial Parkinson’s disease (PD). LRRK2 has two enzymatic domains: a RocCOR tandem with GTPase activity and a kinase domain. In addition, LRRK2 has three N-t...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
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MDPI AG
2023-03-01
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| Edice: | Biomolecules |
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| On-line přístup: | https://www.mdpi.com/2218-273X/13/4/612 |
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