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The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation

Abstract The precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization through interaction with presynaptic r...

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Principais autores: Husam Khaled, Zahra Ghasemi, Mai Inagaki, Kyle Patel, Yusuke Naito, Benjamin Feller, Nayoung Yi, Farin B Bourojeni, Alfred Kihoon Lee, Nicolas Chofflet, Artur Kania, Hidetaka Kosako, Masanori Tachikawa, Steven Connor, Hideto Takahashi
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2024-09-01
Serier:The EMBO Journal
Fag:
Synapse Organizer
Neurotrophin Receptor
Protein Phosphorylation
Avoidance Behavior
Social Novelty
Online adgang:https://doi.org/10.1038/s44318-024-00252-9
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