Pharmacogenomic impact and genetic architecture of toxicity in pediatric acute lymphoblastic leukemia induction therapy: an exploratory modeling approach

Induction chemotherapy for pediatric Acute Lymphoblastic Leukemia (ALL) is highly curative but accompanied by a severe toxicity profile. Evaluating the genetic susceptibility to these adverse events could inform hypothesis-generating risk stratification. In this exploratory retrospective cohort stud...

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Hauptverfasser:	Carolina Gutierrez-Cáceres, Claudio Alarcón-Concha, Javiera Aracena-Farías, Esperanza Torres, Iván Acuña, Tamara Sandoval, Pamela Silva, Maricruz Ormeño, Verónica Oyarce, Leslie C. Cerpa, Matías F. Martínez
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2026-06-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	acute lymphoblastic leukemia adverse drug reaction pediatric oncohematology pharmacogenomics polygenic risk score (PGRS) precision medicine
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1830183/full
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