Remission spectroscopy resolves the mechanism of action of bedaquiline within living mycobacteria

Abstract Bedaquiline, an ATP synthase inhibitor, is the spearhead of transformative therapies against drug-resistant Mycobacterium tuberculosis. Here, we use remission spectroscopy to measure the energy-transducing cytochromes within unperturbed, respiring suspensions of mycobacterial and human cell...

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Detalhes bibliográficos

Principais autores:	Suzanna H. Harrison, Rowan C. Walters, Chen-Yi Cheung, Roger J. Springett, Gregory M. Cook, Morwan M. Osman, James N. Blaza
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-11-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-65928-0
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