Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists

Angiotensin II receptor type 1 and 2 (AT1R and AT2R) are two G-protein coupled receptors that mediate most biological functions of the octapeptide Angiotensin II (Ang II). AT2R is upregulated upon tissue damage and its activation by selective AT2R agonists has become a promising approach in the sear...

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Autori principali:	Silvana Vasile, Anders Hallberg, Jessica Sallander, Mathias Hallberg, Johan Åqvist, Hugo Gutiérrez-de-Terán
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2020-04-01
Serie:	Biomolecules
Soggetti:	angiotensin AT2R agonist free energy perturbation (FEP) G-protein coupled receptor (GPCR) molecular dynamics (MD) peptidomimetics
Accesso online:	https://www.mdpi.com/2218-273X/10/4/649
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