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Targeted inhibition of HER-2 positive breast cancer cells by trastuzumab functionalized pullulan-doxorubicin nanoparticles

Human epidermal growth factor receptor-2 (HER-2) positive breast cancer is highly invasive with poor clinical outcomes and high risk of recurrence. Here, trastuzumab functionalized pullulan-doxorubicin nanoparticles (Tz-P-Dox) were developed and characterized as a new anticancer formulation for acti...

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Principais autores: Ruiling Xu, Junhui Sui, Mingda Zhao, Yuedi Yang, Lei Tong, Yongmei Liu, Yong Sun, Yujiang Fan, Jie Liang, Xingdong Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-09-01
Serier:Polymer Testing
Fag:
HER-2 overexpression
Breast cancer
Trastuzumab
Pullulan-doxorubicin nanoparticles
Targeted inhibition
Online adgang:http://www.sciencedirect.com/science/article/pii/S0142941822001921
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