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Structural analysis of the Toll-like receptor 15 TIR domain

Toll-like receptors (TLRs) activate innate immunity in response to pathogen-associated molecular patterns (PAMPs). The ectodomain of a TLR directly senses a PAMP and the intracellular TIR domain dimerizes to initiate a signaling cascade. The TIR domains of TLR6 and TLR10, which belong to the TLR1 su...

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Principais autores: Kyung Yeol Ko, Wan Seok Song, Jeongho Park, Geun-Shik Lee, Sung-il Yoon
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2023-05-01
Serier:IUCrJ
Fag:
tlr15
toll-like receptors
tir domains
dimers
protein structure
molecular recognition
x-ray crystallography
Online adgang:http://scripts.iucr.org/cgi-bin/paper?S2052252523002956
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