HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation

ABSTRACT The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an immunoproteasome (iProteasome). iProt...

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Bibliografski detalji

Glavni autori:	Yang Yang, Weiyong Liu, Dan Hu, Rui Su, Man Ji, Yuqing Huang, Muhammad Adnan Shereen, Xiaodi Xu, Zhen Luo, Qi Zhang, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2020-10-01
Serija:	mBio
Teme:	antigen presentation negative regulatory factor Nef human immunodeficiency virus type 1 HIV-1 immunoproteasome
Online pristup:	https://journals.asm.org/doi/10.1128/mBio.02221-19
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