DNA Polymerases Engineered by Directed Evolution to Incorporate Nonstandard Nucleotides

DNA polymerases have evolved for billions of years to accept natural nucleoside triphosphate substrates with high fidelity and to exclude closely related structures, such as the analogous ribonucleoside triphosphates. However, polymerases that can accept unnatural nucleoside triphosphates are desire...

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Bibliografische Detailangaben

Hauptverfasser:	Roberto eLaos, John Michael Thomson, Steven Albert Benner
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2014-10-01
Schriftenreihe:	Frontiers in Microbiology
Schlagworte:	Protein Engineering CSR Directed Evolution DNA polymerases AEGIS nonstandard nucleotides
Online-Zugang:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00565/full
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