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Efficacy and Safety of Dose-Escalated Alectinib in Patients With Metastatic ALK-Positive NSCLC and Central Nervous System Relapse on Standard-Dose Alectinib

Introduction: Central nervous system (CNS) metastases remain a common challenge in patients with ALK-positive NSCLC. We previously reported reinduction of CNS responses using dose-intensified alectinib in two patients with CNS progression on standard-dose alectinib. Nevertheless, this strategy has n...

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Wedi'i Gadw mewn:
Prif Awduron: Justin M. Cheung, MD, Jiyoon Kang, DO, Beow Y. Yeap, ScD, Jennifer L. Peterson, BS, Andrew Do, BS, Justin F. Gainor, MD, Subba R. Digumarthy, MD, Jessica J. Lin, MD
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2024-03-01
Cyfres:JTO Clinical and Research Reports
Pynciau:
Alectinib
CNS
Brain metastases
ALK
NSCLC
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2666364324000158
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