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Distribution of HLA-B Alleles and Haplotypes in Qatari: Recommendation for Establishing Pharmacogenomic Markers Screening for Drug Hypersensitivity

Human leukocyte antigen (HLA) proteins are present at the cellular surface of antigen-presenting cells and play a crucial role in the adaptive immune response. Class I genes, specifically certain HLA-B alleles, are associated with adverse drug reactions (ADRs) and are used as pharmacogenetic markers...

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Autors principals: Mohammed Dashti, Abdullah Al-Matrouk, Arshad Channanath, Prashantha Hebbar, Fahd Al-Mulla, Thangavel Alphonse Thanaraj
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2022-08-01
Col·lecció:Frontiers in Pharmacology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fphar.2022.891838/full
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