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Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition

Abstract Background In obesity, excessive energy intake and the expansion of adipose tissue increase ROS generation, contributing to adipocyte dysfunction and inflammation, which leads to abnormal adipose tissue remodeling (ATR). Alpha lipoamide (ALM) is the neutral amide form of lipoic acid, a natu...

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Principais autores: Kegang Linghu, Longkun Hu, Yu-E. Wang, Yuxia Zhou, Yuanyuan Wang, Mingjun Shi, Lirong Liu, Hua Yu, Lei Tang, Ligen Lin, Bing Guo, Ai Tian, Tian Zhang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Chinese Medicine
Fag:
Abnormal adipose tissue remodeling
Alpha lipoamide
Autophagy
Obesity
Nano-emulsion
NLRP3 inflammasome
Online adgang:https://doi.org/10.1186/s13020-025-01253-4
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