Cranial base synostosis in mice caused by upregulation of Wnt following partial inhibition of Shh

Abstract Background The cranial base develops from multipotent mesenchymal cells through endochondral ossification. Genetic ablation of Sonic hedgehog (Shh) or Smoothened (Smo) leads to early apoptosis of cranial base cells, thus limiting the study of their role in the early development of cranial b...

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Bibliografiset tiedot

Päätekijät:	Jiangping Chen, Chengyan Ren, Chuanqing Mao, Yongzhen Lai, Meng Lu, Yuanjing Jiang, Weihui Chen
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2025-08-01
Sarja:	BMC Biology
Aiheet:	Sonic hedgehog Vismodegib Cranial base Synchondrosis Wnt
Linkit:	https://doi.org/10.1186/s12915-025-02381-x
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