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Coding transcriptome analyses reveal altered functions underlying immunotolerance of PEG-fused rat sciatic nerve allografts

Abstract Background Current methods to repair ablation-type peripheral nerve injuries (PNIs) using peripheral nerve allografts (PNAs) often result in poor functional recovery due to immunological rejection as well as to slow and inaccurate outgrowth of regenerating axonal sprouts. In contrast, ablat...

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Principais autores: Tyler A. Smith, Cameron L. Ghergherehchi, Haley O. Tucker, George D. Bittner
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-10-01
Serier:Journal of Neuroinflammation
Fag:
Axotomy
Wallerian degeneration
Polyethylene glycol (PEG)
Transplantation
Allograft rejection
Nerve repair
Online adgang:http://link.springer.com/article/10.1186/s12974-020-01953-8
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