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Differential scanning calorimetry of whole Escherichia coli treated with the antimicrobial peptide MSI-78 indicate a multi-hit mechanism with ribosomes as a novel target

Differential Scanning Calorimetry (DSC) of intact Escherichia coli (E. coli) was used to identify non-lipidic targets of the antimicrobial peptide (AMP) MSI-78. The DSC thermograms revealed that, in addition to its known lytic properties, MSI-78 also has a striking effect on ribosomes. MSI-78’s effe...

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Библиографические подробности
Главные авторы: Alexander M. Brannan, William A. Whelan, Emma Cole, Valerie Booth
Формат: Artigo
Язык:Inglês
Опубликовано: PeerJ Inc. 2015-12-01
Серии:PeerJ
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Online-ссылка:https://peerj.com/articles/1516.pdf
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