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Comparative Metabolic Pathways Analysis and Subtractive Genomics Profiling to Prioritize Potential Drug Targets Against Streptococcus pneumoniae

Streptococcus pneumoniae is a notorious pathogen that affects ∼450 million people worldwide and causes up to four million deaths per annum. Despite availability of antibiotics (i.e., penicillin, doxycycline, or clarithromycin) and conjugate vaccines (e.g., PCVs), it is still challenging to treat bec...

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Principais autores: Kanwal Khan, Khurshid Jalal, Ajmal Khan, Ahmed Al-Harrasi, Reaz Uddin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-02-01
Serier:Frontiers in Microbiology
Fag:
Streptococcus pneumoniae
subtractive genomics
serotype 14
metabolic pathways
4-oxalocrotonate tautomerase and sensor histidine kinase
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2021.796363/full
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