Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

Summary: The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes the N2,N2-dimethylguanosine (m2,2G) modification in tRNAs. Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) paralog. Here, we use a comprehensive tRNA sequencing approach to decipher targets of human...

Cijeli opis

Bibliografski detalji

Glavni autori:	Kejia Zhang, Aidan C. Manning, Jenna M. Lentini, Jonathan Howard, Felix Dalwigk, Reza Maroofian, Stephanie Efthymiou, Patricia Chan, Sergei I. Eliseev, Zi Yang, Hayley Chang, Ehsan Ghayoor Karimiani, Behnoosh Bakhshoodeh, Henry Houlden, Stefanie M. Kaiser, Todd M. Lowe, Dragony Fu
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-01-01
Serija:	Cell Reports
Teme:	CP: Molecular biology
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2211124724014438
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!