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Network pharmacology and in vivo experimental studies reveal the protective effects of 6-hydroxygenistein against hypobaric hypoxia-induced brain injury

Hypobaric hypoxia-induced brain injury (HHBI) is a progressive neurodegenerative disease that has still not been effectively treated. There are several different mechanisms involved in HHBI. Among them, oxidative stress and inflammation response predominate. 6-hydroxygenistein (4′,5,6,7-tetrahydroxy...

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Principais autores: Zhiqun Shi, Jie Zhang, Huiping Ma, Linlin Jing
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-08-01
Serier:Heliyon
Fag:
6-Hydroxygenistein
Hypobaric hypoxia
Brain injury
Network pharmacology
Molecular mechanism
Oxidative stress
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024122724
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