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Transcriptome-guided identification of a four-component system, SbrH1-R, that modulates milbemycin biosynthesis by influencing gene cluster expression, precursor supply, and antibiotic efflux

Streptomyces can produce numerous antibiotics and many other bioactive compounds. Recently, the molecular mechanisms of transcriptional regulators in control of antibiotic production by influencing the expression of biosynthetic gene clusters (BGCs) have been extensively studied. However, for regula...

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Bibliografiset tiedot
Päätekijät: Lan Ye, Yanyan Zhang, Shanshan Li, Hairong He, Guomin Ai, Xiangjing Wang, Wensheng Xiang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: KeAi Communications Co., Ltd. 2022-06-01
Sarja:Synthetic and Systems Biotechnology
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Linkit:http://www.sciencedirect.com/science/article/pii/S2405805X22000102
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