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Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone

pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NET...

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Principais autores: Cristiane Naffah de Souza, Leandro C. D. Breda, Meraj A. Khan, Sandro Rogério de Almeida, Niels Olsen Saraiva Câmara, Neil Sweezey, Nades Palaniyar
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-01-01
Serier:Frontiers in Immunology
Fag:
NET
NOX-independent
pH
calcium
mitochondrial ROS
PAD4
Online adgang:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01849/full
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