Replacement of the Mouse LD₅₀ Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Botulinum neurotoxins (BoNTs) are important therapeutic agents. The in vivo median lethal dose (LD₅₀) assay has been commonly used to measure the potency of BoNT commercial preparations. As an alternative, we developed cell-based assays for abobotulinumtoxinA in both powder (Dysport<sup>®...

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Principais autores:	Elena Fonfria, Elizabeth Marks, Lisa-Marie Foulkes, Rebecca Schofield, Daniel Higazi, Sam Coward, Alistair Kippen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-04-01
coleção:	Toxins
Assuntos:	botulinum toxin LD<sub>50</sub> CBA potency replacement
Acesso em linha:	https://www.mdpi.com/2072-6651/15/5/314
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