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MCL1 inhibition to enhance the efficacy of MYB targeting in pediatric acute myeloid leukemia

Abstract Outcomes for pediatric acute myeloid leukemia (AML) have improved significantly in recent years. However, relapsed and refractory disease remains a significant problem. The chemotherapy burden experienced by these patients makes the translational development of non-genotoxic experimental th...

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Principais autores: Alexia Tsakaneli, Noelia Che, Clemence Virely, Bryony McCord, Luca Gasparoli, Aerin Loe, Kent Fung, Olivia Ciampa, Nuriye Meryem Alver, Qingyin Li, Jack Bartram, David O’Connor, Marc Mansour, Owen Williams
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2026-05-01
coleção:Cell Death and Disease
Acesso em linha:https://doi.org/10.1038/s41419-026-08847-2
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