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The KRT15 and KRT81 complex promotes lenvatinib resistance in thyroid cancer by upregulating DGKB mediated lipid metabolism

Abstract Lenvatinib resistance is a major clinical obstacle in the treatment of radioiodine-refractory papillary thyroid cancer (PTC). Clarification of the molecular mechanisms of this resistance is of utmost importance to devise effective therapeutic strategies. We investigated the role of Keratin...

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Principais autores: Yunjun Wang, Yu Zhang, Dan Zhao, Yi Wu, Tian Liao, Yu Wang, Jun Xiang, Qi Chen, Tuanqi Sun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-04-01
Serier:Scientific Reports
Fag:
Lenvatinib resistance
Thyroid cancer
KRT15
KRT81
DGKB
Lipid metabolism
Online adgang:https://doi.org/10.1038/s41598-026-47994-6
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