A shark-derived broadly neutralizing nanobody targeting a highly conserved epitope on the S2 domain of sarbecoviruses

Abstract The continuously evolving Omicron subvariants has diminished the effectiveness of almost all RBD-targeted antibodies in neutralizing these subvariants. The development of broad-spectrum neutralizing antibodies is desired for addressing both current and future variants. Here, we identified a...

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Bibliografiske detaljer

Principais autores:	Bo Feng, Cuiyun Li, Zhaoyong Zhang, Yongming Huang, Banghui Liu, Zhengyuan Zhang, Jia Luo, Qian Wang, Li Yin, Si Chen, Ping He, Xiaoli Xiong, Jincun Zhao, Xuefeng Niu, Zhilong Chen, Ling Chen
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2025-02-01
Serier:	Journal of Nanobiotechnology
Fag:	Shark nanobody SARS-CoV-2 Sarbecovirus Broad spectrum neutralization
Online adgang:	https://doi.org/10.1186/s12951-025-03150-2
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