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Development of a genetic priority score to predict drug side effects using human genetic evidence

Abstract Many drug failures in clinical trials are due to inadequate safety profiles. We developed an in-silico side effect genetic priority score (SE-GPS) that leverages human genetic evidence to inform side effect risk for a given drug target. We construct the SE-GPS in the Open Target dataset usi...

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Principais autores: Áine Duffy, Robert Chen, David Stein, Joshua K. Park, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N. Cooper, Daniel M. Jordan, Ghislain Rocheleau, Ron Do
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-09-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-025-63762-y
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