Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium

<b>Background:</b><i>Salmonella</i> Typhimurium is a major zoonotic pathogen, in which type 1 fimbriae play a crucial role in intestinal colonization and immune modulation. This study aimed to improve the protective immunity of a previously developed growth-deficient strain—a double auxotroph for D-...

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Detalhes bibliográficos

Principais autores:	Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-06-01
coleção:	Vaccines
Assuntos:	live auxotrophic vaccines type 1 fimbriae FimH mucosal vaccine fecal IgA <i>Salmonella</i> Typhimurium
Acesso em linha:	https://www.mdpi.com/2076-393X/13/6/659
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