Defective mitochondrial unfolded protein response in cancer acts as a lifeline for tumor growth and survival

Defective mitochondrial unfolded protein response (UPRmt) plays an important role in driving tumor growth and treatment resistance. Under physiological conditions, UPRmt preserves mitochondrial protein homeostasis and structure by inducing chaperones such as heat shock proteins (HSP60, HSP70, HSP10)...

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Autori principali:	Uttam Sharma, Vaishnavi Vishwas, Rajiv Ranjan Kumar, Nikita Agarwal, Akshi Shree, Jaya Kanta Gorain, Archana Sasi, Surender K. Sharawat, Archna Singh, Jayanth Kumar Palanichamy, Sameer Bakhshi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-02-01
Serie:	Cell Stress & Chaperones
Soggetti:	Mitochondrial unfolded protein response UPRmt Chaperones Proteases Cancer
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1355814525000884
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