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Global computational alignment of tumor and cell line transcriptional profiles

The determination of whether cancer cell lines recapitulate the molecular features of corresponding patient tumours remains essential for the selection of appropriate cell line models for preclinical studies. The method developed here, Celligner, integrates cancer cell line and tumour RNA-seq datase...

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Bibliografiset tiedot
Päätekijät: Allison Warren, Yejia Chen, Andrew Jones, Tsukasa Shibue, William C. Hahn, Jesse S. Boehm, Francisca Vazquez, Aviad Tsherniak, James M. McFarland
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Portfolio 2021-01-01
Sarja:Nature Communications
Linkit:https://doi.org/10.1038/s41467-020-20294-x
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