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Effect of intravenous clarithromycin in patients with sepsis, respiratory and multiple organ dysfunction syndrome: a randomized clinical trial

Abstract Background Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple...

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Principais autores: Eleni Karakike, Brendon P. Scicluna, Maria Roumpoutsou, Ioannis Mitrou, Niki Karampela, Athanasios Karageorgos, Konstantinos Psaroulis, Eleni Massa, Achillefs Pitsoulis, Panagiotis Chaloulis, Evanthia Pappa, Irene T. Schrijver, Frantzeska Frantzeskaki, Malvina Lada, Nicolas Dauby, David De Bels, Ioannis Floros, Souzana Anisoglou, Eleni Antoniadou, Maria Patrani, Glykeria Vlachogianni, Eleni Mouloudi, Anastasia Antoniadou, David Grimaldi, Thierry Roger, W. Joost Wiersinga, Iraklis Tsangaris, Evangelos J. Giamarellos-Bourboulis
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-06-01
coleção:Critical Care
Assuntos:
Macrolides
Clarithromycin
Sepsis
Multiple organ dysfunction
Recurrence
Cholesterol
Acesso em linha:https://doi.org/10.1186/s13054-022-04055-4
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