IL-8 positive cancer-associated fibroblasts drive breast cancer progression and immune evasion: insights from GWAS and single-cell transcriptomics

Abstract Background Interleukin-8 (IL-8) is a key inflammatory mediator in the tumor microenvironment (TME), where cancer-associated fibroblasts (CAFs) drive breast cancer progression by secreting various cytokines. This study investigates the role of IL-8 positive CAFs in breast cancer pathogenesis...

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Autores principales:	Huifeng Liao, Huayan Li, Yanyu Qu, Liling Tang, Peixian Chen, Tiancheng He, Kun Zhang, Wei Li, Shuqing Yang, Jiawei Lin, Jin Lv, Xiaoyu Gu, Xiangwei Liu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-02-01
Colección:	BMC Cancer
Materias:	IL-8 Cancer-associated fibroblasts Mendelian randomization analysis ScPagwas BayesPrism
Acceso en línea:	https://doi.org/10.1186/s12885-026-15716-w
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