Antitumor Effects In Vitro and In Vivo and Mechanisms of Protection against Melanoma B16F10-Nex2 Cells By Fastuosain, a Cysteine Proteinase from Bromelia fastuosa

In the present work, the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa, was investigated. In the intravenous model of lung colonization in C57BI/6 mice, fastuosain and bromelain injected intraperitoneally were protective, very few nodules of B16F10-Nex2 melanoma cells...

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Detalhes bibliográficos

Principais autores:	Carla A. Guimarães-Ferreira, Elaine G. Rodrigues, Renato A. Mortara, Hamilton Cabral, Fabiana A. Serrano, Ricardo Ribeiro-dos-Santos, Luiz R. Travassos
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2007-09-01
Colecção:	Neoplasia: An International Journal for Oncology Research
Assuntos:	Fastuosain bromelain B16F10-Nex2 tumor cells cathepsins B/L, protective antibodies
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1476558607800327
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