Plasmodium vivax latent liver infection is characterized by persistent hypnozoites, hypnozoite-derived schizonts, and time-dependent efficacy of primaquine

Plasmodium vivax is a malaria-causing pathogen that establishes a dormant form in the liver (the hypnozoite), which can activate weeks, months, or years after the primary infection to cause a relapse, characterized by secondary blood-stage infection. These asymptomatic and undetectable latent liver...

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Autori principali:	Erika L. Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Wanlapa Roobsoong, Matthew Fishbaugher, Kevin Zhou, Zachary P. Billman, Thomas Martinson, Tayla M. Olsen, Carola Schäfer, Brice Campo, Sean C. Murphy, Sebastian A. Mikolajczak, Stefan H.I. Kappe, Jetsumon Sattabongkot
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2022-09-01
Serie:	Molecular Therapy: Methods & Clinical Development
Soggetti:	Plasmodium vivax malaria latency hypnozoite primaquine liver-chimeric humanized mice
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2329050122001085
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