SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine

Summary: Interleukin (IL)-6 is abundantly expressed in the tumor microenvironment and is associated with poor patient outcomes. Here, we demonstrate that the deletion of the suppressor of cytokine signaling 3 (SOCS3) in T cells potentiates anti-tumor immune responses by conferring the anti-tumorigen...

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Bibliografische Detailangaben

Hauptverfasser:	Setsuko Mise-Omata, Makoto Ando, Tanakorn Srirat, Kensuke Nakagawara, Taeko Hayakawa, Mana Iizuka-Koga, Hiroshi Nishimasu, Osamu Nureki, Minako Ito, Akihiko Yoshimura
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2023-08-01
Schriftenreihe:	Cell Reports
Schlagworte:	CP: Cancer
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124723009518
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