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Pyridinium- and bromine-substituted distyryl-BODIPY dyes for mitochondria-targeted photodynamic therapy

Abstract A series of 1-methylpyridinium-substituted brominated distyryl-BODIPY dyes, PyBXI (X = H, M, or Br), was synthesized to achieve cooperative singlet oxygen (1O2) production through qualitatively different dual intersystem crossing (ISC) pathways: spin–orbit charge-transfer ISC (SOCT-ISC) and...

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Principais autores: Chanwoo Kim, Isabel Wen Badon, Jinwoong Jo, Seungyeon Baek, Mina Son, Tae Hun Heo, Duy Khuong Mai, Joomin Lee, Jong Min Lim, Ho-Joong Kim, Juwon Oh, Jaesung Yang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-01-01
Serier:Scientific Reports
Fag:
Distyryl-BODIPY
Spin–orbit charge-transfer intersystem crossing
Heavy atom effect
Singlet oxygen
Photodynamic therapy
Mitochondrion
Online adgang:https://doi.org/10.1038/s41598-026-36213-x
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